Propranolol resolution using enantioselective biphasic systems

• Biphasic systems were here proposed as enantioseparation platforms for chiral drugs. Two types of biphasic evaluated, the ABS and conventional ELLE. CILs esters tartaric acid used selectors. ELLE best option R / S -PRP resolution. CPC enabled an efficient scale-up developed process. The commercialization drugs is increasing concern in pharmacological field since differences activities enantiomers may result serious problems treatment diseases using racemates. resolution important development safer more active pharmaceuticals. This work aims to develop platform propranolol ( R/S -PRP) resorting ionic liquids (CILs) selectors systems. More specifically, efficiency enantioselective liquid–liquid extraction (ELLE) systems, both aqueous non-aqueous are studied, aiming do a direct comparison between these two -PRP. Studies carried evaluate proper phase forming components ELLE, -PRP:chiral selector ratio, potential over acid, most suitable alkyl chain length acid. It was found that selected organic formers 1,2-dichloroethane ethyl acetate, greatly impact enantiorecognition system. system identified composed 1,2-dichloroethane-water, dipentyl-L-tartrate boric selectors, with enantioselectivity 2.54. further employed centrifugal partition chromatography, assess its scalability potential, being shown it possible increase purity from 59% 75%.